PSPC1 Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Together with NONO, required for the formation of nuclear paraspeckles. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. Belongs to the PSPC family. Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 13q12.11
Cellular Component:  cytoplasm; fibrillar center; nuclear matrix; nuclear speck; nucleoplasm; paraspeckles
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; protein binding
Biological Process:  activation of innate immune response; innate immune response; negative regulation of transcription, DNA-templated; regulation of circadian rhythm; regulation of transcription by RNA polymerase II; rhythmic process
Reference #:  Q8WXF1 (UniProtKB)
Alt. Names/Synonyms: DKFZp566B1447; FLJ10955; Paraspeckle component 1; Paraspeckle protein 1; PSP1; PSPC1
Gene Symbols: PSPC1
Molecular weight: 58,744 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Select Structure to View Below

PSPC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB