PSPC1 Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line. Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Together with NONO, required for the formation of nuclear paraspeckles. Belongs to the PSPC family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA-binding
Chromosomal Location of Human Ortholog: 13q12.11
Cellular Component:  cytoplasm; fibrillar center; nuclear matrix; nuclear speck; nucleoplasm; paraspeckles
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; protein binding
Biological Process:  activation of innate immune response; innate immune response; negative regulation of transcription, DNA-templated; regulation of circadian rhythm; regulation of transcription by RNA polymerase II; rhythmic process
Reference #:  Q8WXF1 (UniProtKB)
Alt. Names/Synonyms: DKFZp566B1447; FLJ10955; Paraspeckle component 1; Paraspeckle protein 1; PSP1; PSPC1
Gene Symbols: PSPC1
Molecular weight: 58,744 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
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PSPC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB