PLEKHA4 Binds specifically to phosphatidylinositol 3-phosphate (PtdIns3P), but not to other phosphoinositides. Highly expressed in melanoma. Detected at low levels in heart, skeletal muscle, kidney, liver and small intestine. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 19q13.33
Cellular Component:  cytoplasm; plasma membrane
Molecular Function:  phosphatidylinositol-3-phosphate binding
Biological Process:  phosphatidylinositol biosynthetic process
Reference #:  Q9H4M7 (UniProtKB)
Alt. Names/Synonyms: PEPP-1; PEPP1; PH domain-containing family A member 4; phosphoinositol 3-phosphate binding protein-1; phosphoinositol 3-phosphate-binding PH domain protein 1; Phosphoinositol 3-phosphate-binding protein 1; PKHA4; pleckstrin homology domain containing A4; pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4; Pleckstrin homology domain-containing family A member 4; PLEKHA4
Gene Symbols: PLEKHA4
Molecular weight: 85,401 Da
Basal Isoelectric point: 10.57  Predict pI for various phosphorylation states
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PLEKHA4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein