KHSRP Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. Belongs to the KHSRP family. Detected in neural and non-neural cell lines. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cytoplasmic stress granule; cytosol; nucleoplasm
Molecular Function:  DNA binding; mRNA 3'-UTR AU-rich region binding; protein binding
Biological Process:  3'-UTR-mediated mRNA destabilization; cellular response to cytokine stimulus; miRNA metabolic process; mRNA catabolic process; mRNA processing; mRNA transport; negative regulation of low-density lipoprotein particle clearance; negative regulation of nitric oxide biosynthetic process; positive regulation of mRNA catabolic process; regulation of miRNA metabolic process; regulation of mRNA stability; regulation of transcription, DNA-templated; RNA splicing; RNA splicing, via transesterification reactions
Reference #:  Q92945 (UniProtKB)
Alt. Names/Synonyms: epididymis secretory sperm binding protein; Far upstream element-binding protein 2; FBP2; FUBP2; FUSE binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KH-type splicing regulatory protein; KHSRP; KSRP; MGC99676; p75
Gene Symbols: KHSRP
Molecular weight: 73,115 Da
Basal Isoelectric point: 6.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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KHSRP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB