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KHSRP
Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs. Belongs to the KHSRP family. Detected in neural and non-neural cell lines. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus
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Molecular Function:
DNA binding; mRNA 3'-UTR AU-rich region binding; mRNA binding; protein binding; protein folding chaperone
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Biological Process:
3'-UTR-mediated mRNA destabilization; cellular response to cytokine stimulus; miRNA metabolic process; mRNA processing; mRNA transport; negative regulation of low-density lipoprotein particle clearance; negative regulation of nitric oxide biosynthetic process; positive regulation of mRNA catabolic process; protein folding; regulation of DNA-templated transcription; regulation of gene expression; regulation of mRNA stability; RNA splicing; RNA splicing, via transesterification reactions
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Reference #:
Q92945
(UniProtKB)
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Alt. Names/Synonyms: epididymis secretory sperm binding protein; Far upstream element-binding protein 2; FBP2; FUBP2; FUSE binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein; KH-type splicing regulatory protein; KHSRP; KSRP; MGC99676; p75
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Gene Symbols: KHSRP
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Molecular weight:
73,115 Da
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Basal Isoelectric point:
6.85
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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