CLTC Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Two different adapter protein complexes link the clathrin lattice either to the plasma membrane or to the trans-Golgi network. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension. Plays a role in early autophagosome formation. Belongs to the clathrin heavy chain family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of human Ortholog: 17q23.1
Cellular Component:  clathrin coat; clathrin coat of coated pit; clathrin coat of trans-Golgi network vesicle; clathrin complex; clathrin-coated endocytic vesicle; clathrin-coated endocytic vesicle membrane; clathrin-coated vesicle; cytosol; endolysosome membrane; endosome; lysosome; melanosome; mitotic spindle; mitotic spindle microtubule; plasma membrane; protein-containing complex; spindle; trans-Golgi network membrane
Molecular Function:  clathrin light chain binding; disordered domain specific binding; double-stranded RNA binding; low-density lipoprotein particle receptor binding; protein binding; protein kinase binding; structural molecule activity; ubiquitin-specific protease binding
Biological Process:  amyloid-beta clearance by transcytosis; autophagy; cell division; clathrin coat assembly; clathrin-dependent endocytosis; intracellular protein transport; mitotic cell cycle; negative regulation of hyaluronan biosynthetic process; negative regulation of protein localization to plasma membrane; receptor internalization; receptor-mediated endocytosis; regulation of mitotic spindle organization; retrograde transport, endosome to Golgi; transferrin transport
Disease: Mental Retardation, Autosomal Dominant 56
Reference #:  Q00610 (UniProtKB)
Alt. Names/Synonyms: CHC; CHC17; clathrin heavy chain; Clathrin heavy chain 1; Clathrin heavy chain on chromosome 17; clathrin, heavy chain (Hc); clathrin, heavy polypeptide (Hc); clathrin, heavy polypeptide-like 2; CLH-17; CLH1; CLH17; CLTC; CLTCL2; Hc; KIAA0034; MRD56
Gene Symbols: CLTC
Molecular weight: 191,615 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  B Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein