PGM5 Component of adherens-type cell-cell and cell-matrix junctions. Lacks phosphoglucomutase activity. Belongs to the phosphohexose mutase family. Detected in smooth and cardiac muscle at high levels and in skeletal muscle at low level. Present in other tissues due to vascular or other smooth muscle component. Low levels are present in liver, kidney, skin and brain (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of human Ortholog: 9q21.11
Cellular Component:  cell-cell adherens junction; costamere; cytoplasmic side of plasma membrane; dystrophin-associated glycoprotein complex; focal adhesion; intercalated disc; sarcolemma; spot adherens junction; stress fiber
Molecular Function:  magnesium ion binding; structural molecule activity
Biological Process:  cell adhesion; glucose metabolic process
Reference #:  Q15124 (UniProtKB)
Alt. Names/Synonyms: Aciculin; PGM-RP; PGM5; PGMRP; phosphoglucomutase 5; Phosphoglucomutase-like protein 5; Phosphoglucomutase-related protein
Gene Symbols: PGM5
Molecular weight: 62,225 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene