POLR2L DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component:  cytosol; nucleoplasm; nucleus; RNA polymerase II, core complex
Molecular Function:  DNA binding; protein binding
Biological Process:  7-methylguanosine mRNA capping; fibroblast growth factor receptor signaling pathway; mRNA splicing, via spliceosome; positive regulation of gene expression, epigenetic; positive regulation of type I interferon production; positive regulation of viral transcription; regulation of gene silencing by miRNA; regulation of transcription by RNA polymerase I; RNA metabolic process; snRNA transcription by RNA polymerase II; somatic stem cell population maintenance; termination of RNA polymerase I transcription; transcription by RNA polymerase II; transcription by RNA polymerase III; transcription elongation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; transcription initiation from RNA polymerase I promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-templated; transcription-coupled nucleotide-excision repair
Reference #:  P62875 (UniProtKB)
Alt. Names/Synonyms: DNA-directed RNA polymerase III subunit L; DNA-directed RNA polymerases I, II, and III subunit RPABC5; hRPB7.6; hsRPB10b; POLR2L; polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa; RBP10; RNA polymerase II 7.6 kDa subunit; RNA polymerases I, II, and III subunit ABC5; RPAB5; RPABC5; RPB10; RPB10 homolog; RPB10beta; RPB7.6
Gene Symbols: POLR2L
Molecular weight: 7,645 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
CST Pathways:  Protein Acetylation
Select Structure to View Below


Protein Structure Not Found.

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