H2AFY iso1 Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. Isoform 1: Binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation. Increases the expression of genes involved in redox metabolism, including SOD3. Isoform 2: Represses SOD3 gene expression. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of human Ortholog: 5q31.1
Cellular Component:  Barr body; chromatin; condensed chromosome; nuclear chromosome; nucleolus; nucleoplasm; nucleosome; pericentric heterochromatin; sex chromatin
Molecular Function:  chromatin DNA binding; DNA binding; double-stranded methylated DNA binding; enzyme binding; nucleosomal DNA binding; promoter-specific chromatin binding; protein binding; protein heterodimerization activity; protein kinase binding; protein serine/threonine kinase inhibitor activity; rDNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; structural constituent of chromatin; transcription cis-regulatory region binding
Biological Process:  dosage compensation; epigenetic regulation of gene expression; establishment of protein localization to chromatin; negative regulation of cell cycle G2/M phase transition; negative regulation of gene expression, epigenetic; negative regulation of protein localization to chromosome, telomeric region; negative regulation of protein serine/threonine kinase activity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription of nucleolar large rRNA by RNA polymerase I; nucleosome assembly; positive regulation of endodermal cell differentiation; positive regulation of keratinocyte differentiation; positive regulation of maintenance of mitotic sister chromatid cohesion; regulation of lipid metabolic process; regulation of rDNA heterochromatin formation; regulation of response to oxidative stress; transcription initiation-coupled chromatin remodeling
Reference #:  O75367-1 (UniProtKB)
Alt. Names/Synonyms: Core histone macro-H2A.1; H2A histone family member Y; H2A histone family, member Y; H2A.y; H2A/y; H2AF12M; H2AFJ; H2AFY; H2AY; Histone H2A.y; Histone macroH2A1; histone macroH2A1.1; histone macroH2A1.2; macroH2A.1 histone; MACROH2A1; MACROH2A1.1; macroH2A1.2; Medulloblastoma antigen MU-MB-50.205; mH2A1
Gene Symbols: MACROH2A1
Molecular weight: 39,617 Da
Basal Isoelectric point: 9.8  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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H2AFY iso1

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein