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BIN2
Promotes cell motility and migration, probably via its interaction with the cell membrane and with podosome proteins that mediate interaction with the cytoskeleton. Modulates membrane curvature and mediates membrane tubulation. Plays a role in podosome formation. Inhibits phagocytosis. Detected in natural killer cells (at protein level). Highest level expression seen in spleen and peripheral blood leukocytes and is also expressed at high levels in thymus, colon and placenta, suggesting preferential expression in hematopoietic tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 12q13.13 |
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Cellular Component:
anchoring junction; cell cortex; cell projection; extracellular region; ficolin-1-rich granule lumen; phagocytic cup; plasma membrane; podosome; secretory granule lumen
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Molecular Function:
phospholipid binding; protein binding
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Biological Process:
cell chemotaxis; phagocytosis, engulfment; plasma membrane tubulation; podosome assembly
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Reference #:
Q9UBW5
(UniProtKB)
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Alt. Names/Synonyms: BIN2; BRAP-1; BRAP1; breast cancer associated protein BRAP1; Breast cancer-associated protein 1; Bridging integrator 2; bridging integrator-2
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Gene Symbols: BIN2
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Molecular weight:
61,874 Da
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Basal Isoelectric point:
5.11
Predict pI for various phosphorylation states
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