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MCC
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation. Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity. Belongs to the MCC family. Expressed in a variety of tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Tumor suppressor |
| Chromosomal Location of rat Ortholog: 18p11 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus; plasma membrane
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Molecular Function:
calcium ion binding
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Biological Process:
establishment of protein localization; negative regulation of canonical Wnt signaling pathway; negative regulation of epithelial cell migration; negative regulation of epithelial cell proliferation
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Reference #:
NP_001164005
(RefSeq)
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Alt. Names/Synonyms: Mcc; mutated in colorectal cancers; RGD1561988
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Gene Symbols: Mcc
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Molecular weight:
112,458 Da
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Basal Isoelectric point:
5.31
Predict pI for various phosphorylation states
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