KIF7 Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog (Shh) and Indian hedgehog (Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and -independent mechanisms. Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes. Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation. Involved in the regulation of epidermal differentiation and chondrocyte development. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIF27 subfamily. Embryonic stem cells, melanotic melanoma and Jurkat T-cells. Expressed in heart, lung, liver, kidney, testis, retina, placenta, pancreas, colon, small intestin, prostate and thymus. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 1q31
Cellular Component:  ciliary basal body; cilium; kinesin complex; microtubule
Molecular Function:  ATP binding; ATPase activity; identical protein binding; microtubule binding; microtubule motor activity
Biological Process:  aorta development; cardiac septum development; coronary vasculature development; microtubule-based movement; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway
Reference #:  D4A9P0 (UniProtKB)
Alt. Names/Synonyms: Kif7; Kinesin family member 7
Gene Symbols: Kif7
Molecular weight: 150,578 Da
Basal Isoelectric point: 6.44  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Select Structure to View Below

KIF7

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein