DOCK10 Guanine nucleotide-exchange factor (GEF) that activates CDC42 and RAC1 by exchanging bound GDP for free GTP. Essential for dendritic spine morphogenesis in Purkinje cells and in hippocampal neurons, via a CDC42-mediated pathway. Sustains B-cell lymphopoiesis in secondary lymphoid tissues and regulates FCER2/CD23 expression. Belongs to the DOCK family. Expressed at low level in brain and lung. Isoform 1 is enriched in normal T-cells, isoform 3 is enriched in normal B-cells and chronic lymphocytic leukemia (CLL) B-cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34
Cellular Component:  cytoplasm; cytosol; dendritic spine; nucleoplasm; nucleus
Molecular Function:  guanyl-nucleotide exchange factor activity; Rho GTPase binding; Rho guanyl-nucleotide exchange factor activity
Biological Process:  B cell homeostasis; dendritic spine morphogenesis; marginal zone B cell differentiation; positive regulation of GTPase activity; regulation of cell migration
Reference #:  XP_001060744 (RefSeq)
Alt. Names/Synonyms: dedicator of cytokinesis 10; DOCK10; RGD1561963; similar to Dedicator of cytokinesis protein 10 (Protein zizimin 3)
Gene Symbols: RGD1561963
Molecular weight: 269,013 Da
Basal Isoelectric point: 7.32  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene