K18 Involved in the uptake of thrombin-antithrombin complexes by hepatic cells. When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection. Belongs to the intermediate filament family. Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Nucleolus
Chromosomal Location of human Ortholog: 12q13.13
Cellular Component:  cell periphery; centriolar satellite; cytoplasm; cytosol; intermediate filament; keratin filament; microtubule organizing center; nucleolus; perinuclear region of cytoplasm
Molecular Function:  protein binding; scaffold protein binding; structural molecule activity
Biological Process:  anatomical structure morphogenesis; cell cycle; cell-cell adhesion; cornification; extrinsic apoptotic signaling pathway; Golgi to plasma membrane CFTR protein transport; hepatocyte apoptotic process; intermediate filament cytoskeleton organization; keratinization; negative regulation of apoptotic process; tumor necrosis factor-mediated signaling pathway; viral process
Disease: Cirrhosis, Familial
Reference #:  P05783 (UniProtKB)
Alt. Names/Synonyms: Cell proliferation-inducing gene 46 protein; cell proliferation-inducing protein 46; CK-18; CYK18; cytokeratin 18; Cytokeratin-18; K18; K1C18; keratin 18; keratin 18, type I; Keratin, type I cytoskeletal 18; Keratin-18; KRT18
Gene Symbols: KRT18
Molecular weight: 48,058 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein