DDX30 RNA-dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Associates with mitochondrial DNA. Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD. Belongs to the DEAD box helicase family. DEAH subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; RNA-binding
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  cytoplasm; cytosol; mitochondrial nucleoid; mitochondrion; ribonucleoprotein granule
Molecular Function:  ATP binding; ATP-dependent RNA helicase activity; chromatin binding; double-stranded RNA binding; protein binding; RNA binding
Biological Process:  central nervous system development; DNA duplex unwinding; mitochondrial large ribosomal subunit assembly
Disease: Neurodevelopmental Disorder With Severe Motor Impairment And Absent Language
Reference #:  Q7L2E3 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent RNA helicase DHX30; DDX30; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 30; DEAH (Asp-Glu-Ala-His) box polypeptide 30; DEAH box protein 30; DHX30; FLJ11214; KIAA0890; Putative ATP-dependent RNA helicase DHX30; RETCOR; retina co-repressor
Gene Symbols: DHX30
Molecular weight: 133,938 Da
Basal Isoelectric point: 8.99  Predict pI for various phosphorylation states
Select Structure to View Below

DDX30

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein