ARHGAP17 Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. Ubiquitously expressed. Expressed at higher level in heart and placenta. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of human Ortholog: 16p12.1
Cellular Component:  bicellular tight junction; cytosol; intracellular anatomical structure; plasma membrane
Molecular Function:  GTPase activator activity; protein binding; SH3 domain binding
Biological Process:  actin filament organization; calcium-ion regulated exocytosis; positive regulation of GTPase activity; regulation of actin cytoskeleton organization; regulation of Rac protein signal transduction; signal transduction
Reference #:  Q68EM7 (UniProtKB)
Alt. Names/Synonyms: ARHGAP17; DKFZp564A1363; FLJ37567; FLJ43368; MGC87805; MST066; MST110; MSTP038; MSTP066; MSTP110; NADRIN; neuron-associated developmentally regulated protein; PP367; PP4534; RHG17; Rho GTPase activating protein 17; Rho GTPase-activating protein 17; Rho-type GTPase-activating protein 17; RhoGAP interacting with CIP4 homologs 1; RhoGAP interacting with CIP4 homologs protein 1; RICH-1; RICH1; RICH1B; WBP15
Gene Symbols: ARHGAP17
Molecular weight: 95,437 Da
Basal Isoelectric point: 7.22  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein