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KIF4A
Motor protein that translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis. May play a role in mitotic chromosomal positioning and bipolar spindle stabilization. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Chromokinesin subfamily. Highly expressed in hematopoietic tissues, fetal liver, spleen, thymus and adult thymus and bone marrow. Lower levels are found in heart, testis, kidney, colon and lung. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Microtubule-binding; Motor |
| Chromosomal Location of rat Ortholog: Xq22 |
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Cellular Component:
microtubule associated complex; midbody; nucleoplasm
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Molecular Function:
ATP binding; microtubule binding; microtubule motor activity
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Biological Process:
microtubule-based movement; mitotic cytokinesis; mitotic spindle midzone assembly; mitotic spindle organization; spindle elongation
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Reference #:
E9PSJ3
(UniProtKB)
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Alt. Names/Synonyms: Kif4; KIF4A; kinesin family member 4; Kinesin family member 4A; kinesin heavy chain member 4
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Gene Symbols: Kif4a
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Molecular weight:
139,682 Da
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Basal Isoelectric point:
6.08
Predict pI for various phosphorylation states
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