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LRRFIP1
Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. Belongs to the LRRFIP family. Ubiquitously expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; RNA-binding |
| Chromosomal Location of rat Ortholog: 9q36 |
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Cellular Component:
cytoplasm; cytosol; nucleus; plasma membrane
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Molecular Function:
DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding
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Biological Process:
negative regulation of transcription by RNA polymerase II; positive regulation of NF-kappaB transcription factor activity; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II
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Reference #:
Q66HF9
(UniProtKB)
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Alt. Names/Synonyms: leucine rich repeat (in FLII) interacting protein 1; Leucine-rich repeat flightless-interacting protein 1; LRR FLII-interacting protein 1; LRRF1; Lrrfip1
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Gene Symbols: Lrrfip1
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Molecular weight:
80,019 Da
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Basal Isoelectric point:
4.71
Predict pI for various phosphorylation states
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