AMD1
Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. Belongs to the eukaryotic AdoMetDC family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; EC 4.1.1.50; Lyase
Chromosomal Location of rat Ortholog: 20q12
Cellular Component:
cytosol
Molecular Function:
adenosylmethionine decarboxylase activity; identical protein binding; putrescine binding
Biological Process:
polyamine metabolic process; S-adenosylmethionine metabolic process; spermidine biosynthetic process; spermine biosynthetic process
Reference #:
P17708
(UniProtKB)
Alt. Names/Synonyms: adenosylmethionine decarboxylase 1; AdoMetDC; Amd1; Amd1a; Amd1b; DCAM; S-adenosylmethionine decarboxylase 1; S-adenosylmethionine decarboxylase 1A; S-Adenosylmethionine decarboxylase 1B; S-adenosylmethionine decarboxylase alpha chain; S-adenosylmethionine decarboxylase beta chain; S-adenosylmethionine decarboxylase proenzyme; SAMDC
Gene Symbols: Amd1
Molecular weight:
38,137 Da
Basal Isoelectric point:
5.7
Predict pI for various phosphorylation states
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AMD1
1I72 - A=69-334, B=1-67 (human)
1I79 - A=69-334, B=1-67 (human)
1I7B - A=69-334, B=1-67 (human)
1I7C - A=69-334, B=1-67 (human)
1I7M - A/C=69-334, B/D=1-67 (human)
1JEN - A/C=69-334, B/D=1-67 (human)
1JL0 - A/B=1-334 (human)
1MSV - A/B=1-334 (human)
3DZ2 - A=69-334 B=1-67 (human)
3DZ3 - A=69-334 B=1-67 (human)
3DZ4 - A=69-334 B=1-67 (human)
3DZ5 - A=69-334 B=1-67 (human)
3DZ6 - A=69-334 B=1-67 (human)
3DZ7 - A=69-334 B=1-67 (human)
3EP3 - A=69-328 B=1-67 (human)
3EP4 - A=69-328 B=1-67 (human)
3EP5 - A=69-328 B=1-67 (human)
3EP6 - A=69-328 B=1-67 (human)
3EP7 - A=69-328 B=1-67 (human)
3EP8 - A=69-328 B=1-67 (human)
3EP9 - A=69-328 B=1-67 (human)
3EPA - A=69-328 B=1-67 (human)
3EPB - A=69-328 B=1-67 (human)
3H0V - A=69-334 B=1-67 (human)
3H0W - A=69-334 B=1-67 (human)