KLHL25 Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 7|7 D1
Cellular Component:  Cul3-RING ubiquitin ligase complex; cytoplasm
Biological Process:  protein ubiquitination; regulation of translation; regulation of translational initiation; ubiquitin-dependent protein catabolic process
Reference #:  Q8R2P1 (UniProtKB)
Alt. Names/Synonyms: 2810402K13Rik; BC027373; Ectoderm-neural cortex protein 2; ectoderm-neural cortex-1; Enc-1; ENC-2; Enc2; kelch-like 25; kelch-like 25 (Drosophila); Kelch-like protein 25; KLH25; Klhl25; MGC36331
Gene Symbols: Klhl25
Molecular weight: 65,826 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene