|
KLHL25
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. Note: This description may include information from UniProtKB.
|
| Protein type: Unknown function |
| Chromosomal Location of Human Ortholog: 7|7 D1 |
|
Cellular Component:
Cul3-RING ubiquitin ligase complex; cytoplasm
|
|
Biological Process:
protein ubiquitination; regulation of translation; regulation of translational initiation; ubiquitin-dependent protein catabolic process
|
|
Reference #:
Q8R2P1
(UniProtKB)
|
|
Alt. Names/Synonyms: 2810402K13Rik; BC027373; Ectoderm-neural cortex protein 2; ectoderm-neural cortex-1; Enc-1; ENC-2; Enc2; kelch-like 25; kelch-like 25 (Drosophila); Kelch-like protein 25; KLH25; Klhl25; MGC36331
|
|
Gene Symbols: Klhl25
|
|
Molecular weight:
65,826 Da
|
|
Basal Isoelectric point:
6.24
Predict pI for various phosphorylation states
|
