ATP6V1E1 Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the V-ATPase E subunit family. Ubiquitous (PubMed:12036578). High expression in the skin (PubMed:28065471). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial

Chromosomal Location of rat Ortholog: 4q42

Cellular Component: apical plasma membrane; clathrin-coated vesicle membrane; cytoplasm; cytosol; endosome; extrinsic component of synaptic vesicle membrane; microvillus; proton-transporting two-sector ATPase complex, catalytic domain; vacuolar proton-transporting V-type ATPase, V1 domain

Molecular Function: ATPase binding; proton-transporting ATPase activity, rotational mechanism

Biological Process: proton transmembrane transport; synaptic vesicle lumen acidification

Reference #: Q6PCU2 (UniProtKB)

Alt. Names/Synonyms: Atp6e; Atp6e2; Atp6v1e1; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E; ATPase, H+ transporting, lysosomal V1 subunit E1; ATPase, H+ transporting, V1 subunit E; MGC72933; P31; V-ATPase subunit E 1; V-type proton ATPase subunit E 1; vacuolar H(+)-ATPase, E subunit; Vacuolar proton pump subunit E 1; VATE1; VATPase, H+ transporting, lysosomal V1 subunit E1; Vma4

Gene Symbols: Atp6v1e1

Molecular weight: 26,128 Da

Basal Isoelectric point: 8.44 Predict pI for various phosphorylation states

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ATP6V1E1

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