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EI24
Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy. Belongs to the EI24 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of rat Ortholog: 8q21 |
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Cellular Component:
cytosol; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; membrane; nuclear membrane
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Molecular Function:
importin-alpha family protein binding
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Biological Process:
autophagy; cellular response to UV-C; intrinsic apoptotic signaling pathway in response to DNA damage; macroautophagy; negative regulation of cell growth; negative regulation of protein import into nucleus; neuromuscular process controlling balance; positive regulation of intrinsic apoptotic signaling pathway; response to xenobiotic stimulus
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Reference #:
Q4KM77
(UniProtKB)
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Alt. Names/Synonyms: Ei24; etoposide induced 2.4 mRNA; Etoposide-induced protein 2.4 homolog; MGC112713
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Gene Symbols: Ei24
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Molecular weight:
38,893 Da
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Basal Isoelectric point:
9.75
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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