H2AFJ Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of mouse Ortholog: 6|6 G1
Cellular Component:  chromosome; nuclear chromatin; nucleosome; nucleus
Molecular Function:  DNA binding; protein heterodimerization activity
Biological Process:  chromatin organization
Reference #:  Q8R1M2 (UniProtKB)
Alt. Names/Synonyms: E130307C13; H2A histone family, member J; H2a/j; H2af; H2afj; H2AJ; H2J.A histone; Histone H2A.J; MGC118637; OTTMUSP00000025079
Gene Symbols: H2afj
Molecular weight: 14,045 Da
Basal Isoelectric point: 11.05  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene