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H2AFJ
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Belongs to the histone H2A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding |
| Chromosomal Location of mouse Ortholog: 6|6 G1 |
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Cellular Component:
chromosome; nucleosome; nucleus
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Molecular Function:
DNA binding; protein heterodimerization activity; structural constituent of chromatin
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Reference #:
Q8R1M2
(UniProtKB)
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Alt. Names/Synonyms: E130307C13; H2A histone family, member J; H2a/j; H2af; H2afj; H2AJ; H2J.A histone; Histone H2A.J; MGC118637; OTTMUSP00000025079
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Gene Symbols: H2aj
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Molecular weight:
13,914 Da
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Basal Isoelectric point:
11.05
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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