EIF2S3L
As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. Specifically expressed in testis at the mRNA level. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Chromosomal Location of human Ortholog: 12p13.2 |
Cellular Component:
eukaryotic translation initiation factor 2 complex
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Molecular Function:
GTP binding; GTPase activity; translation initiation factor activity; tRNA binding
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Biological Process:
formation of translation preinitiation complex
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Reference #:
Q2VIR3
(UniProtKB)
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Alt. Names/Synonyms: eIF-2-gamma A; eIF-2-gamma A pseudogene; eIF-2-gamma2; eIF-2gA; eIF2gA; EIF2S3B; EIF2S3L; eukaryotic translation initiation factor 2 subunit 3-like protein; Eukaryotic translation initiation factor 2 subunit 3B; Eukaryotic translation initiation factor 2 subunit gamma A; Eukaryotic translation initiation factor 2 subunit gamma A pseudogene; eukaryotic translation initiation factor 2 subunit gamma B; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa; IF2GL; LOC255308; Putative eukaryotic translation initiation factor 2 subunit 3-like protein
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Gene Symbols: EIF2S3B
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Molecular weight:
51,229 Da
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Basal Isoelectric point:
8.67
Predict pI for various phosphorylation states
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