SNX17 May be involved in several stages of intracellular protein trafficking. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)). Belongs to the sorting nexin family. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 5|5 B1
Cellular Component:  cytoplasm; cytoplasmic vesicle; cytosol; early endosome; endosome; endosome membrane; Golgi apparatus; intracellular membrane-bounded organelle; membrane; protein-containing complex
Molecular Function:  lipid binding; low-density lipoprotein particle receptor binding; phosphatidylinositol binding; protein binding; protein C-terminus binding
Biological Process:  aorta development; cardiac septum development; coronary vasculature development; endocytic recycling; intracellular protein transport; protein transport; receptor-mediated endocytosis; retrograde transport, endosome to plasma membrane; signal transduction
Reference #:  Q8BVL3 (UniProtKB)
Alt. Names/Synonyms: 5830447M19Rik; AI790646; D5Ertd260e; mKIAA0064; OTTMUSP00000025620; Snx17; sorting nexin 17; Sorting nexin-17
Gene Symbols: Snx17
Molecular weight: 52,797 Da
Basal Isoelectric point: 7.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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SNX17

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein