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SNX17
Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). Belongs to the sorting nexin family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Vesicle |
| Chromosomal Location of mouse Ortholog: 5|5 B1 |
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Cellular Component:
cytoplasm; cytoplasmic vesicle; cytosol; early endosome; endosome; endosome membrane; Golgi apparatus; intracellular membrane-bounded organelle; membrane; protein-containing complex
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Molecular Function:
lipid binding; low-density lipoprotein particle receptor binding; phosphatidylinositol binding; protein binding
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Biological Process:
aorta development; cardiac septum development; coronary vasculature development; endocytic recycling; intracellular protein transport; kidney development; protein transport; receptor-mediated endocytosis; signal transduction
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Reference #:
Q8BVL3
(UniProtKB)
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Alt. Names/Synonyms: 5830447M19Rik; AI790646; b2b1625.1Clo; D5Ertd260; D5Ertd260e; mKIAA0064; OTTMUSP00000025620; Snx17; sorting nexin 17; Sorting nexin-17
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Gene Symbols: Snx17
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Molecular weight:
52,797 Da
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Basal Isoelectric point:
7.1
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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