UVRAG Versatile protein that is involved in regulation of different cellular pathways implicated in membrane trafficking. Involved in regulation of the COPI-dependent retrograde transport from Golgi and the endoplasmic reticulum by associating with the NRZ complex; the function is dependent on its binding to phosphatidylinositol 3-phosphate (PtdIns(3)P). During autophagy acts as regulatory subunit of the alternative PI3K complex II (PI3KC3-C2) that mediates formation of phosphatidylinositol 3-phosphate and is believed to be involved in maturation of autophagosomes and endocytosis. Activates lipid kinase activity of PIK3C3. Involved in the regulation of degradative endocytic trafficking and cytokinesis, and in regulation of ATG9A transport from the Golgi to the autophagosome; the functions seems to implicate its association with PI3KC3-C2. Involved in maturation of autophagosomes and degradative endocytic trafficking independently of BECN1 but depending on its association with a class C Vps complex (possibly the HOPS complex); the association is also proposed to promote autophagosome recruitment and activation of Rab7 and endosome-endosome fusion events. Enhances class C Vps complex (possibly HOPS complex) association with a SNARE complex and promotes fusogenic SNARE complex formation during late endocytic membrane fusion. In case of negative-strand RNA virus infection is required for efficient virus entry, promotes endocytic transport of virions and is implicated in a VAMP8-specific fusogenic SNARE complex assembly. Involved in maintaining chromosomal stability. Promotes DNA double-strand break (DSB) repair by association with DNA-dependent protein kinase complex DNA-PK and activating it in non-homologous end joining (NHEJ). Required for centrosome stability and proper chromosome segregation. Highly expressed in brain, lung, kidney and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Autophagy
Chromosomal Location of Human Ortholog: 7|7 E1
Cellular Component:  autophagosome membrane; centrosome; chromosome; chromosome, centromeric region; early endosome; endoplasmic reticulum; endosome; late endosome; lysosome; midbody; phagocytic vesicle; protein-containing complex
Molecular Function:  protein binding; SH3 domain binding; SNARE binding
Biological Process:  autophagosome maturation; autophagy; cellular response to DNA damage stimulus; centrosome cycle; chromosome segregation; DNA repair; double-strand break repair via classical nonhomologous end joining; maintenance of Golgi location; receptor catabolic process; regulation of cytokinesis; regulation of protein serine/threonine kinase activity; retrograde vesicle-mediated transport, Golgi to ER; SNARE complex assembly; spindle organization; viral entry into host cell
Reference #:  Q8K245 (UniProtKB)
Alt. Names/Synonyms: 9530039D02Rik; AI648770; BB124205; UV radiation resistance associated; UV radiation resistance associated gene; UV radiation resistance associated protein; UV radiation resistance-associated gene protein; UV radiation resistance-associated protein; Uvrag; Uvrag1; Uvragl
Gene Symbols: Uvrag
Molecular weight: 77,562 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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UVRAG

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene