UVRAG Forms a complex with BECN1, PIK3C3 and PIK3R4. A subpopulation of these complexes also harbor KIAA0226/Rubicon. UVRAG-containing complexes never including ATG14, both forming mutually exclusive complexes with BECN1 through direct competition. Highly expressed in brain, lung, kidney and liver. Note: This description may include information from UniProtKB.
Protein type: Autophagy
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component:  autophagosome membrane; centrosome; chromosome, centromeric region; cytoplasm; early endosome; endoplasmic reticulum; late endosome; lysosome; midbody; phagocytic vesicle
Molecular Function:  protein binding; SH3 domain binding
Biological Process:  autophagosome maturation; autophagy; centrosome cycle; chromosome segregation; DNA repair; double-strand break repair via classical nonhomologous end joining; maintenance of Golgi location; multivesicular body sorting pathway; positive regulation of autophagosome maturation; receptor catabolic process; regulation of cytokinesis; regulation of protein serine/threonine kinase activity; retrograde vesicle-mediated transport, Golgi to ER; spindle organization; viral entry into host cell
Reference #:  Q9P2Y5 (UniProtKB)
Alt. Names/Synonyms: DHTX; disrupted in heterotaxy; p63; UV radiation resistance associated gene; UV radiation resistance-associated gene protein; UVRAG
Gene Symbols: UVRAG
Molecular weight: 78,151 Da
Basal Isoelectric point: 8.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene