SPG11 May play a role in neurite plasticity by maintaining cytoskeleton stability and regulating synaptic vesicle transport. Expressed in all structures of brain, with a high expression in cerebellum. Expressed in cortical projection neurons. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q21.1
Cellular Component:  axon; cytoplasm; cytoplasmic vesicle; cytosol; dendrite; nucleolus; plasma membrane; synapse
Molecular Function:  protein binding
Biological Process:  axo-dendritic transport; axon extension; chemical synaptic transmission; phagosome-lysosome fusion involved in apoptotic cell clearance; synaptic vesicle transport; walking behavior
Disease: Amyotrophic Lateral Sclerosis 5, Juvenile; Charcot-marie-tooth Disease, Axonal, Type 2x; Spastic Paraplegia 11, Autosomal Recessive
Reference #:  Q96JI7 (UniProtKB)
Alt. Names/Synonyms: Colorectal carcinoma-associated protein; DKFZp762B1512; FLJ21439; KIAA1840; spastic paraplegia 11 (autosomal recessive); Spastic paraplegia 11 protein; Spatacsin; SPG11; SPTCS
Gene Symbols: SPG11
Molecular weight: 278,868 Da
Basal Isoelectric point: 5.63  Predict pI for various phosphorylation states
Select Structure to View Below

SPG11

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein