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A2M
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. Secreted in plasma. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 12p13.31 |
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Cellular Component:
extracellular region; extracellular space; platelet alpha granule lumen
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Molecular Function:
brain-derived neurotrophic factor binding; calcium-dependent protein binding; endopeptidase inhibitor activity; enzyme binding; growth factor binding; identical protein binding; interleukin-1 binding; interleukin-8 binding; nerve growth factor binding; protease binding; protein binding; serine-type endopeptidase inhibitor activity; signaling receptor binding; tumor necrosis factor binding
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Biological Process:
acute inflammatory response to antigenic stimulus; acute-phase response; embryonic liver development; luteinization; negative regulation of complement activation, lectin pathway; negative regulation of endopeptidase activity; response to carbon dioxide; response to glucocorticoid; response to nutrient; response to prostaglandin E; stem cell differentiation
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Disease: Alzheimer Disease
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Reference #:
P01023
(UniProtKB)
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Alt. Names/Synonyms: A2M; A2MD; A2MG; Alpha-2-M; Alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863-7
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Gene Symbols: A2M
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Molecular weight:
163,291 Da
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Basal Isoelectric point:
6.03
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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