ARHGAP15 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has activity toward RAC1. Overexpression results in an increase in actin stress fibers and cell contraction. Expressed in lung, liver and lymphoid cells. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of Human Ortholog: 2q22.2-q22.3
Cellular Component:  cytosol; membrane
Molecular Function:  GTPase activator activity
Biological Process:  positive regulation of GTPase activity; regulation of cell shape; regulation of small GTPase mediated signal transduction; signal transduction
Reference #:  Q53QZ3 (UniProtKB)
Alt. Names/Synonyms: ARHGAP15; BM046; RHG15; Rho GTPase activating protein 15; Rho GTPase-activating protein 15; Rho-type GTPase-activating protein 15
Gene Symbols: ARHGAP15
Molecular weight: 54,544 Da
Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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