ASH1L Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me). Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The physiological significance of the H3K9me1 activity is unclear. Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily. Widely expressed, with highest level in brain, heart and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; Cell adhesion; EC; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 3|3 F1
Cellular Component:  bicellular tight junction; cell junction; chromosome; Golgi apparatus; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; histone methyltransferase activity (H3-K36 specific); histone methyltransferase activity (H3-K4 specific); histone methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; transferase activity
Biological Process:  chromatin organization; decidualization; flagellated sperm motility; histone H3-K36 dimethylation; histone H3-K4 methylation; interleukin-6 production; methylation; negative regulation of acute inflammatory response; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of inflammatory response; negative regulation of MAPK cascade; positive regulation of transcription by RNA polymerase II; post-embryonic development; regulation of gene expression; sebaceous gland development; single fertilization; skeletal system development; tarsal gland development; uterine gland development; uterus morphogenesis
Reference #:  Q99MY8 (UniProtKB)
Alt. Names/Synonyms: 8030453L17Rik; Absent small and homeotic disks protein 1 homolog; absent, small, or homeotic 1-like; absent, small, or homeotic discs 1; Ash1; ash1 (absent, small, or homeotic)-like; ash1 (absent, small, or homeotic)-like (Drosophila); ASH1 like histone lysine methyltransferase; ASH1-like protein; Ash1l; chromatin remodeling factor; E430018P19Rik; Histone-lysine N-methyltransferase ASH1L; Kmt2h; Probable histone-lysine N-methyltransferase ASH1L
Gene Symbols: Ash1l
Molecular weight: 331,333 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene