ASH1L a protein methyltransferase that specifically methylates K36 of histone H3 (H3K36me). A member of the trithorax group (trxG) of transcriptional activators that is required for proper expression of Hox genes and is preferentially expressed in haematopoietic stem cells. Widely expressed, with high levels in brain, heart and kidney. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - lysine degradation; Cell adhesion; EC 2.1.1.43; Methyltransferase; Methyltransferase, protein lysine
Chromosomal Location of Human Ortholog: 3|3 F1
Cellular Component:  bicellular tight junction; cell junction; chromosome; Golgi apparatus; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA binding; histone methyltransferase activity (H3-K36 specific); histone methyltransferase activity (H3-K4 specific); histone methyltransferase activity (H3-K9 specific); histone-lysine N-methyltransferase activity; metal ion binding; methyltransferase activity; transferase activity
Biological Process:  chromatin organization; decidualization; flagellated sperm motility; histone H3-K36 dimethylation; histone H3-K4 methylation; interleukin-6 production; methylation; negative regulation of acute inflammatory response; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of inflammatory response; negative regulation of MAPK cascade; positive regulation of transcription by RNA polymerase II; post-embryonic development; regulation of gene expression; sebaceous gland development; single fertilization; skeletal system development; tarsal gland development; uterine gland development; uterus morphogenesis
Reference #:  Q99MY8 (UniProtKB)
Alt. Names/Synonyms: 8030453L17Rik; Absent small and homeotic disks protein 1 homolog; absent, small, or homeotic 1-like; absent, small, or homeotic discs 1; Ash1; ash1 (absent, small, or homeotic)-like (Drosophila); ASH1-like protein; Ash1l; chromatin remodeling factor; E430018P19Rik; Histone-lysine N-methyltransferase ASH1L; Kmt2h; Probable histone-lysine N-methyltransferase ASH1L
Gene Symbols: Ash1l
Molecular weight: 331,333 Da
Basal Isoelectric point: 9.43  Predict pI for various phosphorylation states
CST Pathways:  Histone Methylation
Select Structure to View Below

ASH1L

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene