ANKRD27 May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics. May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7. Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38. Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1. Required for the colocalization of VAMP7 and Rab21, probably on TGN sites. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29. Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rab
Chromosomal Location of Human Ortholog: 19q13.11
Cellular Component:  cytoplasmic vesicle membrane; cytosol; early endosome; late endosome; lysosome; melanosome; plasma membrane; tubular endosome
Molecular Function:  GTPase activator activity; guanyl-nucleotide exchange factor activity; protein binding; Rab GTPase binding
Biological Process:  early endosome to late endosome transport; endosome to melanosome transport; negative regulation of SNARE complex assembly; positive regulation of dendrite morphogenesis; positive regulation of GTPase activity; protein transport; retrograde transport, endosome to plasma membrane
Reference #:  Q96NW4 (UniProtKB)
Alt. Names/Synonyms: ANKRD27; ankyrin repeat domain 27; ankyrin repeat domain 27 (VPS9 domain); Ankyrin repeat domain-containing protein 27; ANR27; DKFZp434L0718; FLJ00040; PP12899; VARP; Vps9 domain and ankyrin-repeat-containing protein; VPS9 domain-containing protein; VPS9-ankyrin-repeat protein
Gene Symbols: ANKRD27
Molecular weight: 116,984 Da
Basal Isoelectric point: 6.42  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene