ICE1 Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies. Belongs to the ICE1 family. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 13|13 C1
Cellular Component:  Cajal body; histone locus body; nuclear body; nucleoplasm; nucleus; transcription elongation factor complex; transcriptionally active chromatin
Biological Process:  positive regulation of intracellular protein transport; positive regulation of protein complex assembly; positive regulation of transcription by RNA polymerase III; snRNA transcription by RNA polymerase II; snRNA transcription by RNA polymerase III
Reference #:  E9Q286 (UniProtKB)
Alt. Names/Synonyms: C77245; Ice1; interactor of little elongation complex ELL subunit 1; Interactor of little elongator complex ELL subunit 1; Kiaa0947; Little elongation complex subunit 1; LOC218333; MGC27742; mKIAA0947
Gene Symbols: Ice1
Molecular weight: 242,254 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein