ICE1 Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies. Belongs to the ICE1 family. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 5p15.32
Cellular Component:  Cajal body; histone locus body; nuclear body; nucleoplasm; transcription elongation factor complex; transcriptionally active chromatin
Molecular Function:  protein binding; protein homodimerization activity
Biological Process:  positive regulation of intracellular protein transport; positive regulation of protein complex assembly; positive regulation of transcription by RNA polymerase III; snRNA transcription by RNA polymerase II; snRNA transcription by RNA polymerase III
Reference #:  Q9Y2F5 (UniProtKB)
Alt. Names/Synonyms: DKFZp781J2344; ICE1; interactor of little elongation complex ELL subunit 1; Interactor of little elongator complex ELL subunit 1; KIAA0947; Little elongation complex subunit 1; LOC23379
Gene Symbols: ICE1
Molecular weight: 247,891 Da
Basal Isoelectric point: 5.32  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB