INPP5F Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling. Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms. Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation. Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus. Functionally important modulator of cardiac myocyte size and of the cardiac response to stress. May play a role as negative regulator of axon regeneration after central nervous system injuries. Ubiquitous (PubMed:11274189). Highly expressed in brain (PubMed:26203138). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.-; Phosphatase, lipid
Chromosomal Location of human Ortholog: 10q26.11
Cellular Component:  axon; clathrin-coated endocytic vesicle; dendrite; early endosome; early endosome membrane; neuronal cell body; recycling endosome
Molecular Function:  inositol monophosphate 1-phosphatase activity; inositol monophosphate 3-phosphatase activity; inositol monophosphate 4-phosphatase activity; phosphatidylinositol phosphate 4-phosphatase activity; phosphatidylinositol phosphate 5-phosphatase activity; protein binding; protein homodimerization activity
Biological Process:  adult locomotory behavior; cardiac muscle hypertrophy in response to stress; clathrin-dependent endocytosis; negative regulation of axon regeneration; negative regulation of peptidyl-serine phosphorylation; negative regulation of tyrosine phosphorylation of STAT protein; phosphatidylinositol biosynthetic process; phosphatidylinositol catabolic process; phosphatidylinositol dephosphorylation; phosphatidylinositol-mediated signaling; positive regulation of receptor recycling; regulation of cell motility; regulation of endocytic recycling; regulation of protein kinase B signaling
Reference #:  Q9Y2H2 (UniProtKB)
Alt. Names/Synonyms: FLJ13081; hSAC2; Inositol polyphosphate 5-phosphatase F; inositol polyphosphate-5-phosphatase F; INPP5F; KIAA0966; MGC131851; MGC59773; MSTP007; MSTPO47; Phosphatidylinositide phosphatase SAC2; Sac domain-containing inositol phosphatase 2; Sac domain-containing phosphoinositide 4-phosphatase 2; Sac domain-containing phosphoinositide 5-phosphatase 2; SAC2
Gene Symbols: INPP5F
Molecular weight: 128,407 Da
Basal Isoelectric point: 6.57  Predict pI for various phosphorylation states
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INPP5F

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein