Fos Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. Belongs to the bZIP family. Fos subfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor
Chromosomal Location of mouse Ortholog: 12 D2|12 39.7 cM
Cellular Component:  cytoplasm; endoplasmic reticulum; membrane; neuron projection; nucleoplasm; nucleus; protein-DNA complex; transcription factor AP-1 complex; transcription factor complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; double-stranded DNA binding; protein binding; protein heterodimerization activity; R-SMAD binding; RNA polymerase II activating transcription factor binding; RNA polymerase II core promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  cellular response to cadmium ion; cellular response to calcium ion; cellular response to extracellular stimulus; cellular response to reactive oxygen species; nervous system development; positive regulation of neuron death; positive regulation of osteoclast differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of gene expression; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to drug; response to muscle stretch; skeletal muscle cell differentiation; SMAD protein signal transduction; transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway
Reference #:  P01101 (UniProtKB)
Alt. Names/Synonyms: c-f; c-fos; Cellular oncogene fos; cfos; D12Rfj; D12Rfj1; FBJ osteosarcoma oncogene; Fos; OTTMUSP00000021331; Proto-oncogene c-Fos; proto-oncogene protein c-fos
Gene Symbols: Fos
Molecular weight: 40,838 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene