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MAPKBP1
Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response. Involved in JNK signaling pathway. Expressed in intestinal mucosa, where it is detected in epithelial cells, endothelial cells, smooth muscle cells and immune cells, such as lymphocytes (PubMed:22700971). Expressed in kidney (PubMed:28089251). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold |
| Chromosomal Location of human Ortholog: 15q15.1 |
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Cellular Component:
cytoplasm; mitotic spindle pole; nucleolus; nucleoplasm
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Molecular Function:
protein binding
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Biological Process:
negative regulation of defense response to bacterium; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of interleukin-8 production; positive regulation of JNK cascade
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Disease: Nephronophthisis 20
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Reference #:
O60336
(UniProtKB)
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Alt. Names/Synonyms: JNK-binding protein 1; JNKBP-1; JNKBP1; KIAA0596; MABP1; MAPKBP1; MGC138851; MGC138852; mitogen activated protein kinase binding protein 1; mitogen-activated protein kinase binding protein 1; mitogen-activated protein kinase binding protein 1-like; Mitogen-activated protein kinase-binding protein 1; NPHP20
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Gene Symbols: MAPKBP1
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Molecular weight:
163,818 Da
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Basal Isoelectric point:
6.31
Predict pI for various phosphorylation states
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