NCOA7 Enhances the transcriptional activities of several nuclear receptors. Involved in the coactivation of different nuclear receptors, such as ESR1, THRB, PPARG and RARA. Belongs to the OXR1 family. Highly expressed in brain. Weakly expressed in mammary gland, ovary, uterus, prostate, stomach, bladder, spinal cord and pancreas. Expressed in cancer cell line. 7 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 6q22.31-q22.32
Cellular Component:  nucleus
Molecular Function:  nuclear receptor binding; nuclear receptor coactivator activity; protein binding
Biological Process:  negative regulation of cellular response to oxidative stress; negative regulation of peptidyl-cysteine S-nitrosylation; positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; response to oxidative stress
Reference #:  Q8NI08 (UniProtKB)
Alt. Names/Synonyms: 140 kDa estrogen receptor-associated protein; dJ187J11.3; ERAP140; ESNA1; Estrogen nuclear receptor coactivator 1; estrogen receptor associated protein 140 kDa; FLJ45605; MGC88425; Nbla00052; Nbla10993; NCOA7; NCOA7-AS; Nuclear receptor coactivator 7; putative protein product of Nbla00052; putative protein product of Nbla10993; TBC/LysM-associated domain containing 4; TLDC4
Gene Symbols: NCOA7
Molecular weight: 106,162 Da
Basal Isoelectric point: 5.43  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein