CSF2RB High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor. Belongs to the type I cytokine receptor family. Type 4 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component:  granulocyte macrophage colony-stimulating factor receptor complex; integral component of plasma membrane; plasma membrane
Molecular Function:  protein binding; signaling receptor activity
Biological Process:  cellular protein metabolic process; cellular response to interleukin-3; cytokine-mediated signaling pathway; interleukin-3-mediated signaling pathway; interleukin-5-mediated signaling pathway; MAPK cascade; respiratory gaseous exchange; response to lipopolysaccharide; signal transduction
Disease: Surfactant Metabolism Dysfunction, Pulmonary, 5
Reference #:  P32927 (UniProtKB)
Alt. Names/Synonyms: beta common cytokine receptor; beta-GM-CSF receptor; betaGMR; CD131; CDw131; colony stimulating factor 2 receptor beta common subunit; colony stimulating factor 2 receptor subunit beta; colony stimulating factor 2 receptor, beta; colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage); colony-stimulating factor-2 receptor, beta, low-affinity; CSF2RB; Cytokine receptor common subunit beta; GM-CSF/IL-3/IL-5 receptor common beta subunit; GM-CSF/IL-3/IL-5 receptor common beta-chain; IL3RB; IL5RB; interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (high affinity); SMDP5
Gene Symbols: CSF2RB
Molecular weight: 97,336 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
CST Pathways:  PI3K/Akt Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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