PARP14 ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Has been shown to catalyze the mono-ADP-ribosylation of STAT1 at 'Glu-657' and 'Glu-705', thus decreasing STAT1 phosphorylation which negatively regulates pro-inflammatory cytokine production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggested that the inhibition of phosphorylation may be the result of sumoylation of STAT1 'Lys-703'. Mono-ADP-ribosylates STAT6; enhancing STAT6-dependent transcription. In macrophages, positively regulates MRC1 expression in response to IL4 stimulation by promoting STAT6 phosphorylation. Mono-ADP-ribosylates PARP9. Expressed in macrophages. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 2.4.2.30; Transcription, coactivator/corepressor; Transferase
Chromosomal Location of Human Ortholog: 3q21.1
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  enzyme binding; NAD+ ADP-ribosyltransferase activity; protein ADP-ribosylase activity; protein binding
Biological Process:  innate immune response; negative regulation of gene expression; negative regulation of interferon-gamma-mediated signaling pathway; negative regulation of tyrosine phosphorylation of STAT protein; positive regulation of interleukin-4-mediated signaling pathway; positive regulation of tyrosine phosphorylation of STAT protein; protein ADP-ribosylation
Reference #:  Q460N5 (UniProtKB)
Alt. Names/Synonyms: ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; B aggressive lymphoma protein 2; B-aggressive lymphoma 2; BAL2; collaborator of STAT6; KIAA1268; PAR14; PARP-14; PARP14; pART8; poly (ADP-ribose) polymerase family, member 14; Poly [ADP-ribose] polymerase 14; poly(ADP-ribose) polymerase family member 14; Protein mono-ADP-ribosyltransferase PARP14
Gene Symbols: PARP14
Molecular weight: 202,800 Da
Basal Isoelectric point: 6.81  Predict pI for various phosphorylation states
Select Structure to View Below

PARP14

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene