VPS13C Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization. Belongs to the VPS13 family. Widely expressed. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 15q22.2
Cellular Component:  cytoplasm; cytosol; mitochondrial outer membrane
Biological Process:  Golgi to endosome transport; mitochondrion organization; negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
Disease: Parkinson Disease 23, Autosomal Recessive Early-onset
Reference #:  Q709C8 (UniProtKB)
Alt. Names/Synonyms: DKFZp686E0570; FLJ21361; KIAA1421; PARK23; vacuolar protein sorting 13 homolog C; vacuolar protein sorting 13 homolog C (S. cerevisiae); vacuolar protein sorting 13C; Vacuolar protein sorting-associated protein 13C; VP13C; VPS13C
Gene Symbols: VPS13C
Molecular weight: 422,390 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein