TET1 Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. In addition to its role in DNA demethylation, plays a more general role in chromatin regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and Polycomb-repressed genes. Involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Also involved in transcription repression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Plays an important role in the tumorigenicity of glioblastoma cells. TET1-mediated production of 5hmC acts as a recruitment signal for the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis. Belongs to the TET family. Expressed in fetal heart, lung and brain, and in adult skeletal muscle, thymus and ovary. Not detected in adult heart, lung or brain. Up-regulated in glioblastoma cells (at protein level) (PubMed:25284789). Note: This description may include information from UniProtKB.
Protein type: DNA-binding; EC 1.14.11.n2; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q21.3
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; iron ion binding; methylcytosine dioxygenase activity; zinc ion binding
Biological Process:  chromatin organization; DNA demethylation; inner cell mass cell differentiation; negative regulation of methylation-dependent chromatin silencing; positive regulation of cell proliferation; positive regulation of histone methylation; positive regulation of transcription by RNA polymerase II; protein O-linked glycosylation; stem cell population maintenance
Reference #:  Q8NFU7 (UniProtKB)
Alt. Names/Synonyms: bA119F7.1; CXXC finger 6; CXXC-type zinc finger protein 6; CXXC6; FLJ10839; FLJ41442; KIAA1676; LCX; Leukemia-associated protein with a CXXC domain; Methylcytosine dioxygenase TET1; Ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet oncogene 1; TET1
Gene Symbols: TET1
Molecular weight: 235,309 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene