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PRICKLE1
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor. Belongs to the prickle / espinas / testin family. Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia). Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 12q12 |
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Cellular Component:
cell trailing edge; cytosol; nuclear membrane; nucleus; proteasome complex
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Molecular Function:
protein binding; protein-containing complex binding; zinc ion binding
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Biological Process:
anterior visceral endoderm cell migration; aorta development; apoptotic process; axonogenesis; basement membrane organization; bone mineralization; cardiac muscle cell development; cell-cell adhesion; cilium assembly; cornea development in camera-type eye; coronary vasculature development; cytoskeleton-dependent intracellular transport; dendrite development; embryonic brain development; embryonic nail plate morphogenesis; epidermal growth factor receptor signaling pathway; establishment of bipolar cell polarity involved in cell morphogenesis; extracellular matrix assembly; eyelid development in camera-type eye; face morphogenesis; focal adhesion disassembly; gene expression; mesenchyme development; mitotic spindle assembly; multicellular organism growth; negative regulation of canonical Wnt signaling pathway; negative regulation of cardiac muscle cell myoblast differentiation; negative regulation of DNA-templated transcription; neural tube closure; neuron projection extension; outflow tract morphogenesis; planar cell polarity pathway involved in axis elongation; polarized secretion of basement membrane proteins in epithelium; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein ubiquitination; post-anal tail morphogenesis; primitive streak formation; protein import into nucleus; renal tubule development; response to electrical stimulus; response to xenobiotic stimulus; tear secretion; tissue homeostasis; vesicle-mediated transport; Wnt signaling pathway, planar cell polarity pathway
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Disease: Epilepsy, Progressive Myoclonic 1b
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Reference #:
Q96MT3
(UniProtKB)
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Alt. Names/Synonyms: EPM1B; FLJ31627; FLJ31937; MGC138902; MGC138903; PRIC1; prickle homolog 1; prickle homolog 1 (Drosophila); prickle planar cell polarity protein 1; prickle-like 1; Prickle-like protein 1; PRICKLE1; REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein; REST/NRSF interacting LIM domain protein; REST/NRSF-interacting LIM domain protein 1; RILP
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Gene Symbols: PRICKLE1
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Molecular weight:
94,300 Da
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Basal Isoelectric point:
5.84
Predict pI for various phosphorylation states
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