AKR1B1 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - pyruvate; EC; Lipid Metabolism - glycerolipid; Oxidoreductase
Chromosomal Location of Human Ortholog: 6 14.87 cM|6 B1
Cellular Component:  cytoplasm; cytosol; extracellular space; mast cell granule; nucleoplasm; paranodal junction; perinuclear region of cytoplasm; plasma membrane bounded cell projection cytoplasm; Schmidt-Lanterman incisure; Schwann cell microvillus
Molecular Function:  alcohol dehydrogenase (NADP+) activity; alditol:NADP+ 1-oxidoreductase activity; glyceraldehyde oxidoreductase activity; oxidoreductase activity; retinal dehydrogenase activity
Biological Process:  cellular hyperosmotic salinity response; cellular response to hydrogen peroxide; cellular response to methylglyoxal; daunorubicin metabolic process; doxorubicin metabolic process; inner medullary collecting duct development; metanephric collecting duct development; monosaccharide metabolic process; naphthalene metabolic process; negative regulation of apoptotic process; norepinephrine metabolic process; oxidation-reduction process; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; regulation of urine volume; renal water homeostasis; response to organic substance; response to water deprivation; retinoid metabolic process; sorbitol biosynthetic process; stress-activated protein kinase signaling cascade; tissue homeostasis
Reference #:  P45376 (UniProtKB)
Alt. Names/Synonyms: Ahr-1; Ahr1; Akr1b1; Akr1b3; aldehyde reductase 1; aldo-keto reductase family 1, member B1 (aldose reductase); aldo-keto reductase family 1, member B3 (aldose reductase); Aldor1; Aldose reductase; ALDR; Aldr1; ALR2; AR; OTTMUSP00000015654
Gene Symbols: Akr1b1
Molecular weight: 35,732 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene