AKR1B1 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls). Belongs to the aldo/keto reductase family. Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - pyruvate; EC; Lipid Metabolism - glycerolipid; Oxidoreductase
Chromosomal Location of Human Ortholog: 7q33
Cellular Component:  cytosol; extracellular space; mast cell granule; nucleoplasm; paranodal junction; perinuclear region of cytoplasm; plasma membrane bounded cell projection cytoplasm; Schmidt-Lanterman incisure; Schwann cell microvillus
Molecular Function:  alditol:NADP+ 1-oxidoreductase activity; allyl-alcohol dehydrogenase activity; electron transfer activity; glyceraldehyde oxidoreductase activity; NADP-retinol dehydrogenase activity; retinal dehydrogenase activity
Biological Process:  C21-steroid hormone biosynthetic process; carbohydrate metabolic process; cellular hyperosmotic salinity response; cellular response to methylglyoxal; cellular response to peptide; daunorubicin metabolic process; doxorubicin metabolic process; electron transport chain; fructose biosynthetic process; inner medullary collecting duct development; maternal process involved in female pregnancy; metanephric collecting duct development; naphthalene metabolic process; negative regulation of apoptotic process; norepinephrine metabolic process; oxidation-reduction process; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; regulation of urine volume; renal water homeostasis; response to thyroid hormone; response to water deprivation; retinoid metabolic process; retinol metabolic process; sorbitol biosynthetic process; stress-activated protein kinase signaling cascade; tissue homeostasis
Reference #:  P15121 (UniProtKB)
Alt. Names/Synonyms: ADR; AKR1B1; Aldehyde reductase; aldehyde reductase 1; aldo-keto reductase family 1 member B; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1 (aldose reductase); Aldose reductase; ALDR; ALDR1; ALR2; AR; Lii5-2 CTCL tumor antigen; low Km aldose reductase; MGC1804
Gene Symbols: AKR1B1
Molecular weight: 35,853 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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