AKR1B1 Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. Belongs to the aldo/keto reductase family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - pyruvate; EC 1.1.1.21; Lipid Metabolism - glycerolipid; Oxidoreductase
Chromosomal Location of Human Ortholog: 7q33
Cellular Component:  cytosol; extracellular space; mast cell granule; nucleoplasm; paranodal junction; perinuclear region of cytoplasm; plasma membrane bounded cell projection cytoplasm; Schmidt-Lanterman incisure; Schwann cell microvillus
Molecular Function:  alditol:NADP+ 1-oxidoreductase activity; allyl-alcohol dehydrogenase activity; electron transfer activity; glyceraldehyde oxidoreductase activity; NADP-retinol dehydrogenase activity; retinal dehydrogenase activity
Biological Process:  C21-steroid hormone biosynthetic process; carbohydrate metabolic process; cellular hyperosmotic salinity response; cellular response to methylglyoxal; cellular response to peptide; daunorubicin metabolic process; doxorubicin metabolic process; electron transport chain; fructose biosynthetic process; inner medullary collecting duct development; maternal process involved in female pregnancy; metanephric collecting duct development; naphthalene metabolic process; negative regulation of apoptotic process; norepinephrine metabolic process; oxidation-reduction process; positive regulation of JAK-STAT cascade; positive regulation of smooth muscle cell proliferation; regulation of urine volume; renal water homeostasis; response to thyroid hormone; response to water deprivation; retinoid metabolic process; retinol metabolic process; sorbitol biosynthetic process; stress-activated protein kinase signaling cascade; tissue homeostasis
Reference #:  P15121 (UniProtKB)
Alt. Names/Synonyms: ADR; AKR1B1; aldehyde reductase 1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1 (aldose reductase); Aldose reductase; ALDR; ALDR1; ALR2; AR; Lii5-2 CTCL tumor antigen; low Km aldose reductase; MGC1804
Gene Symbols: AKR1B1
Molecular weight: 35,853 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Select Structure to View Below

AKR1B1

Protein Structure Not Found.


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