K10 a type I cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Generally associates with K1. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 11 D|11 62.92 cM
Cellular Component:  intermediate filament; keratin filament
Molecular Function:  cytoskeletal protein binding; protein binding; structural molecule activity
Biological Process:  cellular response to calcium ion; epidermis development; epithelial cell differentiation; intermediate filament organization; keratinocyte development; positive regulation of epidermis development
Reference #:  P02535 (UniProtKB)
Alt. Names/Synonyms: 56 kDa cytokeratin; CK-10; cytokeratin 10; Cytokeratin-10; D130054E02Rik; epidermal keratin 10; K10; K1C1; K1C10; keratin 10; keratin complex 1, acidic, gene 10; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 59 kDa; Keratin-10; Krt-1.10; Krt1-10; Krt10; OTTMUSP00000005149; suprabasal cytokeratin 10
Gene Symbols: Krt10
Molecular weight: 57,770 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene