K10 Plays a role in the establishment of the epidermal barrier on plantar skin. (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur. Belongs to the intermediate filament family. Seen in all suprabasal cell layers including stratum corneum. Expressed on the surface of lung cell lines (PubMed:19627498). Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of mouse Ortholog: 11 D|11 62.92 cM
Cellular Component:  cornified envelope; cytoplasm; cytoskeleton; extracellular region; intermediate filament; keratin filament
Molecular Function:  cytoskeletal protein binding; protein binding; protein heterodimerization activity; structural constituent of skin epidermis; structural molecule activity
Biological Process:  cellular response to calcium ion; epidermis development; epithelial cell differentiation; intermediate filament organization; keratinocyte development; keratinocyte differentiation; peptide cross-linking; positive regulation of epidermis development; protein heterotetramerization; stem cell differentiation
Reference #:  P02535 (UniProtKB)
Alt. Names/Synonyms: 56 kDa cytokeratin; CK-10; cytokeratin 10; Cytokeratin-10; D130054E02Rik; epidermal keratin 10; intermediate filament protein; K10; K1C1; K1C10; keratin 10; keratin complex 1, acidic, gene 10; Keratin, type I cytoskeletal 10; Keratin, type I cytoskeletal 59 kDa; Keratin-10; Krt-1.1; Krt-1.10; Krt1-1; Krt1-10; Krt10; OTTMUSP00000005149; suprabasal cytokeratin 10
Gene Symbols: Krt10
Molecular weight: 57,770 Da
Basal Isoelectric point: 5.04  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene