PKDREJ May have a central role in fertilization. May generate a Ca(2+) transporting channel directly involved in initiating the acrosome reaction of the sperm. Belongs to the polycystin family. Exclusively expressed in testis. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15|15 E2
Cellular Component:  membrane; plasma membrane
Molecular Function:  calcium channel activity
Biological Process:  detection of mechanical stimulus; regulation of acrosome reaction
Reference #:  Q9Z0T6 (UniProtKB)
Alt. Names/Synonyms: PKD and REJ homolog; PKDRE; Pkdrej; polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly homolog, sea urchin); polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly, sea urchin homolog)-like; Polycystic kidney disease and receptor for egg jelly-related protein; polycystin (PKD) family receptor for egg jelly; receptor for egg jelly-like protein
Gene Symbols: Pkdrej
Molecular weight: 241,390 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein