mGluR7 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of mouse Ortholog: 6|6 E3
Cellular Component:  asymmetric synapse; axon; axon terminus; cell cortex; cell surface; dendrite; dendritic shaft; GABA-ergic synapse; glutamatergic synapse; Golgi apparatus; membrane; neuronal cell body; plasma membrane; postsynaptic membrane; presynaptic active zone; presynaptic active zone membrane; presynaptic membrane; protein-containing complex; receptor complex; rough endoplasmic reticulum; synapse; terminal bouton
Molecular Function:  adenylate cyclase inhibiting G protein-coupled glutamate receptor activity; adenylate cyclase inhibitor activity; calcium channel regulator activity; calcium ion binding; calcium-dependent protein binding; calmodulin binding; G protein-coupled receptor activity; glutamate binding; glutamate receptor activity; group III metabotropic glutamate receptor activity; identical protein binding; PDZ domain binding; protein dimerization activity; serine binding; voltage-gated calcium channel activity
Biological Process:  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; adult behavior; associative learning; axon development; behavioral fear response; chemical synaptic transmission; conditioned taste aversion; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; glycosylation; memory; multicellular organismal response to stress; negative regulation of glutamate secretion; negative regulation of neuron apoptotic process; nervous system process; presynaptic modulation of chemical synaptic transmission; regulation of neuron death; regulation of synaptic transmission, glutamatergic; regulation of synaptic vesicle exocytosis; response to stimulus; sensory perception of sound; short-term memory; signal transduction; transmission of nerve impulse
Reference #:  Q68ED2 (UniProtKB)
Alt. Names/Synonyms: 6330570A01Rik; BB176677; C030018L03; E130018M02Rik; G protein-coupled receptor GRM7; G protein-coupled receptor, family C, group 1, member G; glutamate receptor, metabotropic 7; Gpr; Gpr1g; Gprc1g; Grm7; Metabotropic glutamate receptor 7; MGC90857; mGlu; mGlu7a receptor; Mglur7; SMN2; Tg(SMN2)89Ahmb
Gene Symbols: Grm7
Molecular weight: 102,219 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene