mGluR7 G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3p26.1
Cellular Component:  asymmetric synapse; axon; cell cortex; dendrite; dendritic shaft; integral component of membrane; integral component of plasma membrane; plasma membrane; postsynaptic membrane; presynaptic active zone; receptor complex
Molecular Function:  adenylate cyclase inhibitor activity; glutamate receptor activity; group III metabotropic glutamate receptor activity; serine binding
Biological Process:  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; chemical synaptic transmission; G protein-coupled receptor signaling pathway; negative regulation of glutamate secretion; regulation of cyclase activity; sensory perception of sound
Disease: Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Imaging Abnormalities
Reference #:  Q14831 (UniProtKB)
Alt. Names/Synonyms: FLJ40498; GLUR7; glutamate metabotropic receptor 7; glutamate receptor, metabotropic 7; GPRC1G; GRM7; Metabotropic glutamate receptor 7; MGLU7; MGLUR7; NEDSHBA; PPP1R87; protein phosphatase 1, regulatory subunit 87
Gene Symbols: GRM7
Molecular weight: 102,251 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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