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mGluR7
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum. Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 3p26.1 |
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Cellular Component:
asymmetric synapse; axon; cell cortex; dendrite; dendritic shaft; membrane; plasma membrane; postsynaptic membrane; presynaptic active zone; receptor complex
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Molecular Function:
adenylate cyclase inhibitor activity; glutamate receptor activity; group III metabotropic glutamate receptor activity; protein dimerization activity; serine binding
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Biological Process:
adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; axon development; behavioral fear response; chemical synaptic transmission; G protein-coupled glutamate receptor signaling pathway; glycosylation; negative regulation of glutamate secretion; regulation of synaptic transmission, glutamatergic; sensory perception of sound
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Disease: Neurodevelopmental Disorder With Seizures, Hypotonia, And Brain Imaging Abnormalities
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Reference #:
Q14831
(UniProtKB)
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Alt. Names/Synonyms: FLJ40498; GLUR7; glutamate metabotropic receptor 7; glutamate receptor, metabotropic 7; GPRC1G; GRM7; Metabotropic glutamate receptor 7; MGLU7; MGLUR7; NEDSHBA; PPP1R87; protein phosphatase 1, regulatory subunit 87
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Gene Symbols: GRM7
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Molecular weight:
102,251 Da
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Basal Isoelectric point:
8.2
Predict pI for various phosphorylation states
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