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NEIL3
Reports about DNA glycosylase activity are contradictory. A number of references report finding no DNA glycosylase activity and the protein lacks a proline residue at the N-terminus which functions as an active site residue in other members of the FPG family. However, the mouse ortholog has been shown to have both DNA glycosylase and AP lyase activities and PubMed:19170771 demonstrates AP lyase activity. Prefers single- stranded DNA or partially single-stranded DNA structures such as bubble and fork structures to double-stranded DNA in vitro. Displays a broad recognition spectrum, preferring FapyA and FapyG followed by 5-OHU, 5-PHC and 5-OHMH and then Tg and 8-oxoA. No activity on 8-oxoG detected. Belongs to the FPG family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; EC 4.2.99.18 |
| Chromosomal Location of Human Ortholog: 4q34.3 |
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Cellular Component:
nucleoplasm; nucleus
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Molecular Function:
bubble DNA binding; class I DNA-(apurinic or apyrimidinic site) endonuclease activity; damaged DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) endonuclease activity; double-stranded DNA binding; single-stranded DNA binding; zinc ion binding
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Biological Process:
base-excision repair; nucleotide-excision repair
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Reference #:
Q8TAT5
(UniProtKB)
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Alt. Names/Synonyms: DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; Endonuclease 8-like 3; Endonuclease VIII-like 3; FGP2; FLJ10858; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3 (E. coli); Nei-like protein 3; NEI3; NEIL3
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Gene Symbols: NEIL3
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Molecular weight:
67,769 Da
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Basal Isoelectric point:
9.23
Predict pI for various phosphorylation states
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