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NEIL3
DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair. Belongs to the FPG family. Expressed in keratinocytes and embryonic fibroblasts (at protein level). Also detected in thymus, testis and fetal lung primary fibroblasts. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; EC 4.2.99.18 |
| Chromosomal Location of human Ortholog: 4q34.3 |
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Cellular Component:
chromosome; nucleoplasm; nucleus
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Molecular Function:
bubble DNA binding; class I DNA-(apurinic or apyrimidinic site) endonuclease activity; damaged DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) endonuclease activity; double-stranded DNA binding; MCM complex binding; single-stranded DNA binding; zinc ion binding
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Biological Process:
base-excision repair; base-excision repair, AP site formation; depurination; interstrand cross-link repair
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Reference #:
Q8TAT5
(UniProtKB)
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Alt. Names/Synonyms: DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; Endonuclease 8-like 3; Endonuclease VIII-like 3; FGP2; FLJ10858; FPG2; hFPG2; hNEI3; nei endonuclease VIII-like 3; nei endonuclease VIII-like 3 (E. coli); nei like DNA glycosylase 3; Nei-like protein 3; NEI3; NEIL3; ZGRF3; zinc finger, GRF-type containing 3
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Gene Symbols: NEIL3
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Molecular weight:
67,769 Da
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Basal Isoelectric point:
9.23
Predict pI for various phosphorylation states
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