PHF6 Transcriptional regulator that associates with ribosomal RNA promoters and suppresses ribosomal RNA (rRNA) transcription. Ubiquitously expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Unknown function
Chromosomal Location of Human Ortholog: Xq26.2
Cellular Component:  condensed chromosome kinetochore; nucleolus; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription repressor activity, RNA polymerase II-specific; enzyme binding; histone binding; histone deacetylase binding; metal ion binding; phosphoprotein binding; protein binding; ribonucleoprotein complex binding; scaffold protein binding; sequence-specific DNA binding; tubulin binding
Biological Process:  blastocyst hatching; negative regulation of transcription by RNA polymerase II
Disease: Borjeson-forssman-lehmann Syndrome
Reference #:  Q8IWS0 (UniProtKB)
Alt. Names/Synonyms: BFLS; BORJ; CENP-31; centromere protein 31; KIAA1823; MGC14797; PHD finger protein 6; PHD-like zinc finger protein; PHF6; truncated PHF6
Gene Symbols: PHF6
Molecular weight: 41,290 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

PHF6

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein